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Electrophysiological defects in a novel patient-derived stem cell model of desmoglein-2 mutant ARVC

ABSTRACT: Here we developed a novel human induced pluripotent stem cell (hiPSC) model of ARVC to gain insight into the electrical and biomolecular effects of desmoglein-2 (DSG2) mutation in cardiomyocytes. hiPSC-derived cardiomyocytes (hiPSC-CMs) were generated from peripheral blood mononuclear cells donated by an ARVC patient with a pathogenic variant in DSG2, c.2358delA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE176209 | GEO | 2021/06/06

REPOSITORIES: GEO

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Electrophysiological defects in a novel patient-derived stem cell model of desmoglein-2 mutant ARVC

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