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Transitions in infant learning are modulated by dopamine within the amygdala

ABSTRACT: Behavioral transitions Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray results showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone injected 8-day-old pups and untreated 12-day-old pups learn aversions and had dopaminergic upregulation in the amygdala.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE17651 | GEO | 2009/09/27

SECONDARY ACCESSION(S): PRJNA118603

REPOSITORIES: GEO

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Transitions in infant learning are modulated by dopamine within the amygdala

Project description:Behavioral transitions Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray results showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone injected 8-day-old pups and untreated 12-day-old pups learn aversions and had dopaminergic upregulation in the amygdala. 8 day saline or corticosterone treated- or 12 day old untreated rat pups were trained with odor-shock pairings. Immediately after training pups were sacrificed and the amygdala dissected out. Controls were unpaired shock-odor groups.Paired and unpaired groups were processed together for each experimental condition. Paired and unpaired data were compared by ranked products.

2009-09-27 | E-GEOD-17651 | biostudies-arrayexpress

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Paradoxical neurobehavioral rescue by cues associated with infant trauma: Amygdala 5-HT and CORT

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Expression data from adrenal glands from normoxic and hypoxic neonatal rats

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