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ChIP-seq analysis of OTX2 in hES-RPE cells

ABSTRACT: OTX2 binding sites were profiled in RPE cells generated from human embryonic stem cells (hES-RPE)

ORGANISM(S): Homo sapiens

PROVIDER: GSE178165 | GEO | 2022/11/21

REPOSITORIES: GEO

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Project description:Otx2 has been shown to be non cell autonomously required for photoreceptor cell survival in the adult mouse RPE. This study aims to identify Otx2 DNA binding profile in both RPE and neural retina to i) identify direct targets of Otx2 in the RPE ii) compare Otx2 binding profile in neural retina and RPE to unveil hidden functions in the neural retina. WT and GFP antibodies were used to perform two independent ChIP-seq experiments using Illumina GAIIx.

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