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Mouse whole brain: Molecular alterations caused by prenatal titanium dioxide nanoparticle exposure

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE178207 | GEO | 2021/10/04

REPOSITORIES: GEO

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Mouse whole brain: Molecular alterations caused by prenatal titanium dioxide nanoparticle exposure

Project description:Mouse whole brain: Molecular alterations caused by prenatal titanium dioxide nanoparticle exposure

| PRJNA737740 | ENA

Mouse whole brain: Alteration of gene expression caused by prenatal titanium dioxide nanoparticle exposure

Project description:Reportedly, titanium dioxide nanoparticle exposure during pregnancy can affect the development of the central nervous system in mouse offspring; however, the underlying mechanism remains unknown. We investigated the impact of prenatal dioxide nanoparticle exposure on mRNA expression patterns in the brains of neonatal mice. Pregnant C57BL/6J mice were intratracheally administered a dioxide nanoparticle suspension (100 ug/mouse) on gestational day 10.5, and brains were collected from male and female offspring at day 1 postpartum. Total RNA was obtained, and mRNA expression profiles were comprehensively assessed using microarray analysis. The results showed 88 and 89 genes were upregulated (≥ 1.5-fold) accompanied by demethylation of CpG islands, whereas 13 and 33 genes were downregulated (≤ 0.67-fold) accompanied by demethylation of CpG islands in male and female offspring mice, respectively. Gene Set Enrichment Analysis (GSEA) revealed that these genes were enriched in gene ontology terms related to the regulation of transcription factors, cell proliferation, and organism development. Additionally, MeSH terms related to stem cells and morphogenesis were enriched.

2021-10-04 | GSE178199 | GEO

Mouse whole brain: Alteration of DNA methylation status caused by prenatal titanium dioxide nanoparticle exposure

Project description:Reportedly, titanium dioxide nanoparticle exposure during pregnancy can affect the development of the central nervous system in mouse offspring; however, the underlying mechanism remains unknown. In the present study, we investigated the impact of prenatal dioxide nanoparticle exposure on global DNA methylation in the brains of neonatal mice. Pregnant C57BL/6J mice were intratracheally administered a dioxide nanoparticle suspension (100 ug/mouse) on gestational day 10.5, and brains were collected from male and female offspring at day 1 postpartum. After extraction of methylated DNA by immunoprecipitation, the DNA methylation profile was analyzed using a mouse CpG island microarray. Among genes in the CpG island microarray, DNA methylation was increased in 614 and 2924 genes and decreased in 6219 and 6463 genes in male and female offspring, respectively. Combined with mRNA microarray analysis, 88 and 89 genes were upregulated (≥ 1.5-fold) accompanied by demethylation of CpG islands, whereas 13 and 33 genes were downregulated (≤ 0.67-fold) accompanied by demethylation of CpG islands in male and female offspring mice, respectively. Gene Set Enrichment Analysis (GSEA) revealed that these genes were enriched in gene ontology terms related to the regulation of transcription factors, cell proliferation, and organism development. Additionally, MeSH terms related to stem cells and morphogenesis were enriched.

2021-10-04 | GSE178202 | GEO

Mouse whole brain: Alteration of gene expression caused by prenatal titanium dioxide nanoparticle exposure

Project description:Mouse whole brain: Alteration of gene expression caused by prenatal titanium dioxide nanoparticle exposure

| PRJNA737660 | ENA

Mouse whole brain: Alteration of DNA methylation status caused by prenatal titanium dioxide nanoparticle exposure

Project description:Mouse whole brain: Alteration of DNA methylation status caused by prenatal titanium dioxide nanoparticle exposure

| PRJNA737755 | ENA

Titanium dioxide nanoparticles exposure

2010-12-22 | GSE17902 | GEO

Effects of titanium dioxide nanoparticle exposure on neuroimmune responses in rat airways.

Project description: Not available

| S-EPMC3655524 | biostudies-literature

Titanium dioxide nanoparticles exposure

Project description:This project utilized oligonucleotide microarrays to examine gene expression patterns in adult male fathead minnows (Pimephales promelas) exposed to a common nanomaterial, titanium dioxide (TiO2, stearate-coated particles, MT-100TV®). We exposed adult male fathead minnows for 96 hr to three doses (0, 1, and 10 mg/L nominal) of TiO2 under static renewal conditions. TiO2 is stearate coated, 15 nm particle size. Three-condition experiment: high dose, controls (untreated, low dose). Three tissues: liver, gill, brain. Biological replicates: 4 control replicates, 4 low dose, 4 high dose for gill and liver. One array for brain control and low dose; and 2 arrays for brain high dose. Contributor: Johnson & Johnson Worldwide Envrionmental

2010-12-22 | E-GEOD-17902 | biostudies-arrayexpress

Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse.

Project description: Not available

| S-EPMC2726979 | biostudies-literature

Group II innate lymphoid cells and microvascular dysfunction from pulmonary titanium dioxide nanoparticle exposure.

Project description: Not available

| S-EPMC6230229 | biostudies-literature