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Tak1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan

ABSTRACT: To determine which genes are affected by NG25 and melphalan, we performed an RNA-seq on INA-6 cells treated with NG25, melphalan or a combination of the two. GSEA focusing on the hallmark pathways showed that melphalan-treatment upregulated genes involved in UV-response, DNA-repair, p53-pathway and TNF-signaling via NF-kB. NG25 induced expression of genes involved in cholesterol homeostasis and mTORC1-signaling and down-regulated MYC- and E2F-targets. MYC is a central driver of MM pathology, and regulate survival as well as cell cycle control through E2F. NG25 reversed the melphalan-induced UV-response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178292 | GEO | 2021/06/17

REPOSITORIES: GEO

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Tak1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan

Project description:Tak1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan

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