Transcriptomics

Dataset Information

0

Whole-transcriptome analysis illustrates evolving transcriptional human response to injury in acute wounds and scars


ABSTRACT: The goal of this study was to use RNA sequencing to identify novel genes involved in wound healing and scar formation in human burn wounds and scars. RNA was isolated from 108 human samples comprising of uninjured skin (n=26), acute burn wounds (n=54), and hypertrophic scars (HTS) (n=30). Genes with at least 1.5-fold change and a p-value less than 0.05 with a false discovery rate of 0.05 were considered differentially expressed. Samples were sequenced using Illumina Hi-Seq sequencers, and pathway/Gene Ontology (GO) Enrichment analysis was conducted using iPathwayGuide. Comparing wounds to uninjured skin, we found 9,311 differentially expressed genes, accounting for 1,017 GO terms. Comparing HTS to uninjured skin, we found 7,299 differentially expressed genes, accounting for 1,022 GO terms. By analyzing the whole transcriptome, we characterized dominant genes expressed temporally in wounds and scars. This study reveals the complexity of these processes and helps to bring novel genes to light.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178411 | GEO | 2024/06/03

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-01-22 | E-MTAB-1323 | biostudies-arrayexpress
2023-02-23 | PXD035749 | Pride
2024-07-21 | GSE234919 | GEO
2024-07-21 | GSE251937 | GEO
2013-05-28 | E-GEOD-44270 | biostudies-arrayexpress
2024-09-13 | GSE264515 | GEO
2024-09-13 | GSE264743 | GEO
2022-12-08 | GSE176360 | GEO
2022-12-08 | GSE207021 | GEO
2022-12-08 | GSE142854 | GEO