Genomics

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Profiling of a series of triple positive (CD10+BCL6+MUM1+) diffuse large B-cell lymphoma cases


ABSTRACT: Gene expression profiling (GEP) divides DLBCL according to the cell of origin into GCB, ABC and unclassifiable, exhibiting different mutational profiles. The Hans algorithm, a surrogate of GEP, classifies cases expressing CD10, BCL6 and MUM1 as GCB but it is not clear whether all these cases correspond to GCB-type. Accordingly, LBCL with IRF4 rearrangement usually expresses GCB phenotype (CD10+, BCL6+) together with strong MUM1/IRF4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178417 | GEO | 2023/06/05

REPOSITORIES: GEO

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