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Modulation of macrophage polarization by HMB [macrophage]

ABSTRACT: to determine whether hydroxymethyl butyrate alters macrophage polarization bone marrow derived macrophages were treated with HMB alone or in combination with LPS for 48h

ORGANISM(S): Mus musculus

PROVIDER: GSE178475 | GEO | 2021/12/29

REPOSITORIES: GEO

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Modulation of macrophage polarization by HMB [muscle]

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Modulation of macrophage polarization by HMB

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:Older individuals subjected to complete bed rest for 10 days were randomized to a complete nutritional supplement with or without hydroxymethyl butyrate (HMB). Muscle biopsies from the vastus lateralis were obtained immediately prior and at the conclusion of the bed rest. RNA-sequencing was performed to determine the gene expression changes associated with bed rest. Marked decrease in the expression of genes associated with mitochondrial energy metabolism including fatty acid oxidation, TCA cycle and the electron transport chain was observed with bed rest. These effects were partly mitigated in the subjects provided the nutritional supplement with HMB.

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