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The expression profiles of AMG510-resistant cancer cells

ABSTRACT: AMG510 is a covalent inhibitor of G12C mutated KRAS. To identify the mechanism of resistance to AMG510, we treated MIA-PaCa2 cells with increasing dose of AMG510 for 2 months and established two population of cells that are resistant to 5 uM AMG510. RNA sequencing was used to extermine the expression profile.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178479 | GEO | 2021/06/19

REPOSITORIES: GEO

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