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JUN promotes hypertrophic skin scarring via CD36

ABSTRACT: Hypertrophic skin scarring following dermal injury causes extreme pain and psychological trauma for patients. Unfortuately, we do not have effective treatments to prevent or reverse skin scarring. Using RNA and ATAC sequencing of mouse and human fibroblasts, we show that JUN expressing fibroblasts are responsible for skin scarring by regulating CD36 expression. In summary, we show that CD36 antagonism by represent a therapeutic target to overcome JUN hypertrophic skin scarring.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE178562 | GEO | 2021/06/22

REPOSITORIES: GEO

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JUN promotes hypertrophic skin scarring via CD36

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