Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis.
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ABSTRACT: Adipocytes are the main cell type in adipose tissue, a critical regulator of metabolism, highly specialized in storing energy as fat. Adipocytes differentiate from multipotent mesenchymal stromal cells through adipogenesis. Using RNA-seq we explored the effect of manipulating NAD+ bioavailability during adipogenic differentiation from human mesenchymal stem cells. Cells were harvested either undifferentiated (hMSC) or after days 8 and 16 of adipogenic induction. During adipogenesis, cells were treated with either NAD+ (5 mM), or FK866 (1 nM) or EX527 (50 μM).
ORGANISM(S): Homo sapiens
PROVIDER: GSE178615 | GEO | 2022/09/16
REPOSITORIES: GEO
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