Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE179053 | GEO | 2021/06/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture (ChIP-Seq)

Project description:Mice harboring a liver-specific carnitine palmityltransferase 2 (Cpt2) knockout exhibit drastic lipid accumulation following a 24hr fast. Crossing Cpt2L-/- mice with Pparα-/- mice provides a model to drive ligand-activated Pparα signaling in liver. We use this to investigate unique patterns of Pparα target gene transcription and demonstrate the requirement for ligand-activated Pparα in maintaining transcriptionally permissive genomic architecture in liver including regulation of promoters and enhancer elements during periods of acute nutrient deprivation.

2021-06-29 | GSE179052 | GEO

Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture (ATAC-Seq)

Project description:Mice harboring a liver-specific carnitine palmityltransferase 2 (Cpt2) knockout exhibit drastic lipid accumulation following a 24hr fast. Crossing Cpt2L-/- mice with Pparα-/- mice provides a model to drive ligand-activated Pparα signaling in liver. We use this to investigate unique patterns of Pparα target gene transcription and demonstrate the requirement for ligand-activated Pparα in maintaining transcriptionally permissive genomic architecture in liver, including regulation of promoters and enhancer elements during periods of nutrient deprivation.

2021-06-29 | GSE179050 | GEO

Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture

Project description:Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture

| PRJNA742022 | ENA

Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture (ATAC-Seq)

Project description:Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture (ATAC-Seq)

| PRJNA742020 | ENA

Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture (ChIP-Seq)

Project description:Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture (ChIP-Seq)

| PRJNA742025 | ENA

Yap regulates fatty acid oxidation in skeletal muscle

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-18 | GSE144138 | GEO

The short 3’ UTR derived sRNA FadZ buffers the transcriptional fluctuations during fatty acid oxidation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-27 | GSE192571 | GEO

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-05-01 | GSE80142 | GEO

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-31 | GSE209686 | GEO

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.

Project description:Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin resistance. Here, we show that fructose and glucose supplementation of an HFD exert divergent effects on hepatic mitochondrial function and fatty acid oxidation. This is mediated via three different nodes of regulation, including differential effects on malonyl-CoA levels, effects on mitochondrial size/protein abundance, and acetylation of mitochondrial proteins. HFD- and HFD plus fructose-fed mice have decreased CTP1a activity, the rate-limiting enzyme of fatty acid oxidation, whereas knockdown of fructose metabolism increases CPT1a and its acylcarnitine products. Furthermore, fructose-supplemented HFD leads to increased acetylation of ACADL and CPT1a, which is associated with decreased fat metabolism. In summary, dietary fructose, but not glucose, supplementation of HFD impairs mitochondrial size, function, and protein acetylation, resulting in decreased fatty acid oxidation and development of metabolic dysregulation.

| S-EPMC7816129 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data