Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Histone H3 proline 16 hydroxylation regulates mammalian gene expression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE179113 | GEO | 2022/08/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Histone H3 proline 16 hydroxylation regulates mammalian gene expression [RNA-Seq]

Project description:Histone posttranslational modifications (PTMs) are important for regulating various DNA-templated processes. Emerging evidence suggests a critical involvement of the previously less-explored histone PTMs in gene activity regulation. Here, we report the existence of a new histone PTM in the mammalian cells, hydroxylation of H3 proline 16 (H3P16-OH) catalyzed by EglN2, a proline hydroxylase. We show that EglN2-mediated H3P16-OH enhances direct binding of Lysine-Specific Demethylase 5A (KDM5A) with its substrate, H3 lysine 4 trimethylation (H3K4me3), resulting in enhanced chromatin recruitment of KDM5A and decrease of H3K4me3 at target genes. Genome-wide mapping by CUT&RUN in multiple mammalian cell models reveals a functional connection between EglN2, H3P16-OH, KDM5A and H3K4me3. Integrated analysis with RNA-Seq also identifies distinct subsets of genes that are regulated through H3P16-OH in different cell lines. This study therefore demonstrates a new player of the “histone code” by revealing a role of H3P16-OH in regulating gene expression in mammalian cells.

2022-08-02 | GSE179112 | GEO

Histone H3 proline 16 hydroxylation regulates mammalian gene expression [CUT&RUN]

2022-08-02 | GSE179108 | GEO

Histone H3 proline 16 hydroxylation regulates mammalian gene expression

Project description:Histone H3 proline 16 hydroxylation regulates mammalian gene expression

| PRJNA742234 | ENA

Histone H3 proline 16 hydroxylation regulates mammalian gene expression [RNA-Seq]

Project description:Histone H3 proline 16 hydroxylation regulates mammalian gene expression [RNA-Seq]

| PRJNA742239 | ENA

Histone H3 proline 16 hydroxylation regulates mammalian gene expression [CUT&RUN]

Project description:Histone H3 proline 16 hydroxylation regulates mammalian gene expression [CUT&RUN]

| PRJNA742238 | ENA

The histone H3 variant H3.3 regulates gene body DNA methylation

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-04-24 | GSE96873 | GEO

Histone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-10 | E-GEOD-75169 | biostudies-arrayexpress

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-05-03 | GSE33130 | GEO

Structural mapping of regulatory function of histone H3 and H4 residues

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-12-05 | E-GEOD-29064 | biostudies-arrayexpress

An RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-31 | E-GEOD-39547 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data