Transcriptomics

Dataset Information

0

Transcriptomic signatures of the aging brain at bulk-tissue resolution


ABSTRACT: Aging is a major risk factor for neurodegenerative diseases that impose tremendous burdens on people and societies today. To understand trajectories of neurological aging in a primate, we generated one of the most comprehensive brain transcriptional datasets to date in a unique population of naturalistic, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expression are associated with neural functions and neurological diseases, including Alzheimer's disease. Further, we demonstrate that higher social status in females is associated with younger relative transcriptional ages, providing a compelling link between the social environment and aging in the brain. Our findings lend insight into biological mechanisms underlying brain aging and indicate promising directions for improving social gradients in neurological health.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE179328 | GEO | 2022/09/26

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-09-26 | GSE179236 | GEO
2021-01-31 | GSE159973 | GEO
2021-08-14 | GSE182032 | GEO
2017-06-21 | GSE87001 | GEO
2022-08-12 | PXD033420 | Pride
2022-08-12 | PXD034449 | Pride
2024-10-02 | GSE278620 | GEO
2019-07-31 | GSE130127 | GEO
2024-04-22 | GSE131040 | GEO
2021-02-01 | GSE162969 | GEO