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Non-equilibrium pronucleus histones require gametal factor Lsm1 induced major satellite RNA decay

ABSTRACT: The development of a multicellular organism with various organs and tissues is a complex but highly concerted process, in which cells acquire different identities through exquisite spatiotemporal regulations called cell fate decision. Here, we Lsm1 targets non-coding major satellite RNAs in mouse zygote, which is required for the non-equilibrium epigenetic modification, especially H3K9me3 establishment during early embryo development.

ORGANISM(S): Mus musculus

PROVIDER: GSE179556 | GEO | 2022/07/05

REPOSITORIES: GEO

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