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A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [dRNA-seq]

ABSTRACT: In a major study, we found that miR-aU14, a potential miRNA expressed by human herpesvirus 6A (HHV-6A), acts to selectively inhibit the processing of members of the human miR-30 family through direct RNA:RNA interaction and causes changes in mitochondrial arcchitecture through p53-Drp1 axis. In order to characterize miR-aU14, we carried out differentia lRNA-seq (dRNA-seq) from HHV-6A lytic infected HSB2 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE179866 | GEO | 2022/02/17

REPOSITORIES: GEO

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A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Lytic infection]

Project description:In a major study, we found that miR-aU14, a potential miRNA expressed by human herpesvirus 6A (HHV-6A), acts to selectively inhibit the processing of members of the human miR-30 family through direct RNA:RNA interaction and causes changes in mitochondrial arcchitecture through p53-Drp1 axis. In order to characterize miR-aU14 during virus reactivation, we carried out small RNA-seq from U2-OS cells carrying latent HHV-6A. Virus reactivation was carried out using 80 ng/ml of Trichostatin-A (TSA).

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A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [dRNA-seq]

Project description:A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [dRNA-seq]

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