Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Antigen-specific CD8+ T cells from tumor draining of melanoma bearing mice

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE180095 | GEO | 2022/10/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

ATAC-seq of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice

2022-10-10 | GSE180084 | GEO

ATAC-seq of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice II

2022-10-10 | GSE214384 | GEO

Antigen-specific CD8+ T cells from tumor draining of melanoma bearing mice

Project description:Antigen-specific CD8+ T cells from tumor draining of melanoma bearing mice

| PRJNA746545 | ENA

scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

Project description:CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors, drive infiltrated tumor-specific CD8+ T cells into a hyporesponsive state known as “exhaustion”. These Tex cells are mainly characterized by the sustained and elevated expression of a series of inhibitory receptors as well as the hierarchical loss of effector functions. Further, the impaired proliferative capacity of exhausted CD8+ T cells results in decreasing numbers of tumor-specific T cells, such that the residual CD8+ T cells within the TME can barely provide sufficient protective immunity against tumor progression. Thus, the maintenance or reinforcement of intratumoral antigen-specific CD8+ T cells is indispensable for tumor repression. Here, we profiled the transcriptional signatures of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice at single-cell level, aiming to draw a comprehensive immune-atlas of tumor-specific CD8 T cells during tumorigenesis.

2022-10-10 | GSE180094 | GEO

ATAC-seq of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice

Project description:ATAC-seq of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice

| PRJNA746488 | ENA

ATAC-seq of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice II

Project description:ATAC-seq of antigen-specific CD8+ T cells from tumor draining LNs of melanoma bearing mice II

| PRJNA885101 | ENA

Antigen cross-presentation in young tumor-bearing hosts promotes CD8 T cell terminal differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-28 | GSE188389 | GEO

tumor-infiltrating CD8+ T cells from tumor-bearing mice transferred Nrf2-deficient CD8+ T cells.

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-01 | GSE229994 | GEO

TIGIT and PD-1 impair tumor antigen-specific CD8? T cells in melanoma patients.

Project description:T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NK cells. Here, we determined that TIGIT is upregulated on tumor antigen-specific (TA-specific) CD8? T cells and CD8? tumor-infiltrating lymphocytes (TILs) from patients with melanoma, and these TIGIT-expressing CD8? T cells often coexpress the inhibitory receptor PD-1. Moreover, CD8? TILs from patients exhibited downregulation of the costimulatory molecule CD226, which competes with TIGIT for the same ligand, supporting a TIGIT/CD226 imbalance in metastatic melanoma. TIGIT marked early T cell activation and was further upregulated by T cells upon PD-1 blockade and in dysfunctional PD-1?TIM-3? TA-specific CD8? T cells. PD-1?TIGIT?, PD-1?TIGIT?, and PD-1?TIGIT? CD8? TILs had similar functional capacities ex vivo, suggesting that TIGIT alone, or together with PD-1, is not indicative of T cell dysfunction. However, in the presence of TIGIT ligand-expressing cells, TIGIT and PD-1 blockade additively increased proliferation, cytokine production, and degranulation of both TA-specific CD8? T cells and CD8? TILs. Collectively, our results show that TIGIT and PD-1 regulate the expansion and function of TA-specific CD8? T cells and CD8? TILs in melanoma patients and suggest that dual TIGIT and PD-1 blockade should be further explored to elicit potent antitumor CD8? T cell responses in patients with advanced melanoma.

| S-EPMC4463210 | biostudies-literature

scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

Project description:scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

| PRJNA746548 | ENA