RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma [m6A-seq]
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ABSTRACT: We here report ALKBH5, a m6A RNA demethylase, as a crucial oncogene in multiple myeloma (MM). Using various MM models, we demonstrated a critical requirement of ALKBH5 for MM cell proliferation in vitro and in vivo. To identify the potential mRNA targets of ALKBH5, we conducted m6A-seq with mRNA samples enriched from MM cells with or without ALKBH5 knockdown.
ORGANISM(S): Homo sapiens
PROVIDER: GSE180207 | GEO | 2022/07/07
REPOSITORIES: GEO
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