Methylation profiling

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RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma [m6A-seq]


ABSTRACT: We here report ALKBH5, a m6A RNA demethylase, as a crucial oncogene in multiple myeloma (MM). Using various MM models, we demonstrated a critical requirement of ALKBH5 for MM cell proliferation in vitro and in vivo. To identify the potential mRNA targets of ALKBH5, we conducted m6A-seq with mRNA samples enriched from MM cells with or without ALKBH5 knockdown.

ORGANISM(S): Homo sapiens

PROVIDER: GSE180207 | GEO | 2022/07/07

REPOSITORIES: GEO

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