Fibrinogen-reactive T cells transfer disease to naïve mice
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ABSTRACT: Splenocytes harvested from mice with FIA were cultured in vitro and stimulated with 0.01 mg/ml fibrinogen for 3 days. Enriched T cells were transferred into 6-week-old naïve SJL mice, which developed visible signs of arthritis within 2 weeks. Synovial array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B cell responses against peptides representing native fibrinogen, and further spreading of the responses to target collagen type V, cartilage gp39, and citrullinated vimentin.
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE18025 | GEO | 2009/09/12
SECONDARY ACCESSION(S): PRJNA123465
REPOSITORIES: GEO
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