Genomics

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Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes


ABSTRACT: We have analyzed changes in histone 3 lysine 4 methylation (H3K4me3 and H3K4me1), histone acetylation (H3K9ac and H3K27ac) and gene expression resulting from Setd1b knockdown in adult hippocampal CA neurons in mice. We implemented Cre/loxP-mediated conditional knockout strategy in order to knockdown this histone methyltransferase in excitatory forebrain neurons in adult mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE180326 | GEO | 2021/09/16

REPOSITORIES: GEO

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