Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE180438 | GEO | 2022/02/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development [ChIP-seq]

Project description:Genome-wide occupancy of PfAP2-EXP2 at the schizont stage

2022-02-02 | GSE180437 | GEO

Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development [RNA-seq]

Project description:Effects of PfAP2-EXP2 knockdown on gene expression at the ring, trophozoite, and schizont stages

2022-02-02 | GSE180436 | GEO

Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development

Project description:Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development

| PRJNA748248 | ENA

PfAP2-EXP2, an Essential Transcription Factor for the Intraerythrocytic Development of <i>Plasmodium falciparum</i>.

Project description:Plasmodium falciparum undergoes a series of asexual replications in human erythrocytes after infection, which are effective targets for combatting malaria. Here, we report roles of an ApiAP2 transcription factor PfAP2-EXP2 (PF3D7_0611200) in the intraerythrocytic developmental cycle of P. falciparum. PfAP2-EXP2 conditional knockdown resulted in an asexual growth defect but without an appreciable effect on parasite morphology. Further ChIP-seq analysis revealed that PfAP2-EXP2 targeted genes related to virulence and interaction between erythrocytes and parasites. Especially, PfAP2-EXP2 regulation of euchromatic genes does not depend on recognizing specific DNA sequences, while a CCCTAAACCC motif is found in its heterochromatic binding sites. Combined with transcriptome profiling, we suggest that PfAP2-EXP2 is participated in the intraerythrocytic development by affecting the expression of genes related to cell remodeling at the schizont stage. In summary, this study explores an ApiAP2 member plays an important role for the P. falciparum blood-stage replication, which suggests a new perspective for malaria elimination.

| S-EPMC8785209 | biostudies-literature

Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development [ChIP-seq]

Project description:Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development [ChIP-seq]

| PRJNA748256 | ENA

Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development [RNA-seq]

Project description:Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development [RNA-seq]

| PRJNA748255 | ENA

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-06-24 | GSE143902 | GEO

A coordinated regulatory network of ApiAP2 transcription factors involved in heterochromatic gene expression during Plasmodium falciparum blood-stage development

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-06 | GSE184659 | GEO

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-06-10 | GSE135006 | GEO

Plasmodium falciparum infection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-15 | E-GEOD-35936 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data