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Next Generation Sequencing Facilitates Quantitative Analysis of Ern1f/f and Ern1f/f AKO iWAT transcriptomes

ABSTRACT: Bulk RNA-seq has uncovered the the function of adipocyte IRE1α in cold-induced thermogenic program in inguinal white adipose tissue. The GO analysis shows that adipocyte IRE1α supressed inflammatory responds when the mice were maintained at 30oC and adipocyte IRE1α abrogation facilated cold-induced thermogenic program after challenged with cold stress. In addition, the transcription factor (TF) analysis indicates that adipocyte IRE1α repressed lots of temperature-dependent TFs, including PGC1α.

ORGANISM(S): Mus musculus

PROVIDER: GSE180524 | GEO | 2022/07/21

REPOSITORIES: GEO

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