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Interferon inducible pseudouridine modification in human mRNA by quantitative nanopore profiling (Nanopore)


ABSTRACT: Pseudouridine (Ψ) is an abundant mRNA modification in the mammalian transcriptome, but its function has remained elusive due to the difficulty of transcriptome-wide mapping. We develop nanopore native RNA sequencing for quantitative Ψ analysis that utilizes native content training, machine learning model prediction, and single read coordination. We find interferon inducible Ψ modifications in the interferon stimulated gene transcripts, consistent with a role of Ψ in the efficacy of mRNA vaccines.

ORGANISM(S): human feces metagenome Homo sapiens Saccharomyces cerevisiae Caenorhabditis elegans Drosophila melanogaster

PROVIDER: GSE180654 | GEO | 2021/11/18

REPOSITORIES: GEO

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