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New-Onset IgG Autoantibodies in Hospitalized Patients with COVID-19

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Escherichia coli Bos taurus Capra aegagrus synthetic construct Sus scrofa Spodoptera frugiperda Homo sapiens Triticum aestivum Cricetulus griseus

PROVIDER: GSE180743 | GEO | 2021/07/24

REPOSITORIES: GEO

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New-Onset IgG Autoantibodies in Hospitalized Patients with COVID-19 [viral]

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New-onset IgG autoantibodies in hospitalized patients with COVID-19.

Project description:COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein arrays to measure IgG autoantibodies associated with connective tissue diseases, anti-cytokine antibodies, and anti-viral antibody responses in serum from 147 hospitalized COVID-19 patients. Autoantibodies are identified in approximately 50% of patients but in less than 15% of healthy controls. When present, autoantibodies largely target autoantigens associated with rare disorders such as myositis, systemic sclerosis and overlap syndromes. A subset of autoantibodies targeting traditional autoantigens or cytokines develop de novo following SARS-CoV-2 infection. Autoantibodies track with longitudinal development of IgG antibodies recognizing SARS-CoV-2 structural proteins and a subset of non-structural proteins, but not proteins from influenza, seasonal coronaviruses or other pathogenic viruses. We conclude that SARS-CoV-2 causes development of new-onset IgG autoantibodies in a significant proportion of hospitalized COVID-19 patients and are positively correlated with immune responses to SARS-CoV-2 proteins.

| S-EPMC8440763 | biostudies-literature