Acute Transcriptomic Response After Mouse Spinal Cord Injury
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ABSTRACT: In order to characterize genomic response and identify molecular marker for acute neural injury, we performed RNA-sequencing 4 hours after spinal cord injury. We found a group of genes with significant differential expression (DEG) after Benjamini-Hochberg FDR multiple corrections. These DEGs mainly include early response genes, neuroinflammation, and cell injury and death. Notely, activating transcription factor 3 (ATF3) is one of the most significantly upregulated genes by 9.9 folds and is a well-recognized molecular marker for DRG sensory neuron injury in peripheral nerve injury model.
ORGANISM(S): Mus musculus
PROVIDER: GSE180767 | GEO | 2021/12/31
REPOSITORIES: GEO
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