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CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response

ABSTRACT: CD44 is a transmembrane adhesion molecule and the major receptor for hyaluronan. The function of CD44 has been implicated in numerous biological processes. Our study finds that zebrafish CD44a variants function as positive regulators in antibacterial response. In order to reveal the possible antibacterial mechanism of CD44a, the wild-type and CD44a-/--14del zebrafish larvaes infected with E. piscicida collected at 24 and 48 hpi were used for transcriptome sequencing. Our data demonstrate that zebrafish CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response.

ORGANISM(S): Danio rerio

PROVIDER: GSE180770 | GEO | 2021/07/26

REPOSITORIES: GEO

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