The Rho guanosine exchange factors Vav2 and Vav3 modulate epidermal stem cell function
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ABSTRACT: It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of its upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the SSC identity and the quiescent state. By contrast, Vav proteins promote transcriptomal programs associated with the identity and activation state of SSCs in cancer stem cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE180946 | GEO | 2022/05/07
REPOSITORIES: GEO
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