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Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 increases tumorigenic potential of normal epithelial cells

ABSTRACT: In this manuscript, we used a non-genetically manipulated EMT/MET cell line model to demonstrate that epithelial mesenchymal plasticity occurring in normal cells generates co-existing phenotypically and functionally divergent cell subpopulations with increased tumorigenic potential in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE181008 | GEO | 2021/07/30

REPOSITORIES: GEO

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Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 increases tumorigenic potential of normal epithelial cells

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