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Transcriptomic response dynamics of human primary and immortalized adrenocortical cells to ACTH and Angiotensin II

ABSTRACT: RNA sequencing provides a transcriptome-wide view of what processes are activated and repressed during steroidogenesis. Here we performed an RNA-seq time series on primary human adrenocortical cells and H295R cells stimulated with ACTH or AngII (forskolin for H295R). We found that the ligand-induced changes in gene expression largely involved the same genes and similar timing. While stimulus-induced expression changes in H295R cells are recapitulated by primary cells, there are also expression changes unique to primary cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE181158 | GEO | 2021/09/29

REPOSITORIES: GEO

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