Transcriptomics

Dataset Information

0

Molecular Signatures of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model


ABSTRACT: In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1 month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. Established HFpEF, 4 months post-banding, resulted in changes in intermediary metabolism with normalized mitochondrial function. Mitochondrial dysfunction and energetic deficiencies were noted in skeletal muscle at early and late phases of disease, suggesting cardiac-derived signaling contributes to peripheral tissue maladaptation in HFpEF. Collectively, these results provide insights into the cellular biology underlying HFpEF progression.

ORGANISM(S): Felis catus

PROVIDER: GSE181184 | GEO | 2021/09/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-10-15 | PXD033501 | Pride
| PRJNA759257 | ENA
2024-03-05 | PXD045677 | Pride
2022-09-16 | GSE184328 | GEO
2022-10-12 | PXD036259 | Pride
2023-03-01 | GSE221195 | GEO
2024-01-17 | GSE249411 | GEO
2024-01-17 | GSE249409 | GEO
2024-01-17 | GSE245034 | GEO
2024-01-18 | GSE249412 | GEO