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SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis

ABSTRACT: Triple-negative breast cancer (TNBC) has a relatively aggressive biological behavior and poor outcome. Our published study showed that PAI-1 could induce the migration and metastasis of TNBC cells. However, the underlying mechanism by which PAI-1 regulates TNBC metastasis has not been addressed. Using microarray analysis of lncRNA expression profiles, we identified a lncRNA SOX2-OT, which is by induced by PAI-1 and could function as an oncogenic lncRNA in TNBC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE181202 | GEO | 2024/05/15

REPOSITORIES: GEO

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