Confined Migration Induces Heterochromatin Formation and Alters Chromatin Accessibility
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ABSTRACT: We show that confined migration results in predominantly decreased chromatin accessibility, consistent with the increased heterochromatin marks staining. A small fraction of ATAC-seq peaks shows increased accessibility at gene promoters of diverse pathways, such as chromatin silencing, tumor invasion, and DNA damage response; whereas the majority shows decreased accessibility at intergenic regions near centromeres or telomeres, suggesting possible heterochromatin spreading.
ORGANISM(S): Homo sapiens
PROVIDER: GSE181247 | GEO | 2022/08/10
REPOSITORIES: GEO
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