Genomics

Dataset Information

0

The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly


ABSTRACT: The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood. In fission yeast, the JmjC domain protein Epe1 is critical for maintaining the heterochromatin landscape. Loss of Epe1 results in heterochromatin expansion and overexpression of Epe1 leads to defective heterochromatin. Through a genetic screen, we found that mutations in genes of the cAMP signaling pathway suppress the heterochromatin defects associated with Epe1 overexpression. We further demonstrated that the activation of Pka1, the downstream effector of cAMP signaling, is required for the efficient translation of epe1+ mRNA to maintain Epe1 overexpression. Moreover, inactivating the cAMP-signaling pathway, either through genetic mutations or glucose deprivation, leads to the reduction of endogenous Epe1 and corresponding heterochromatin changes. These results reveal the mechanism by which the cAMP signaling pathway regulates heterochromatin landscape in fission yeast.

ORGANISM(S): Schizosaccharomyces pombe

PROVIDER: GSE181263 | GEO | 2022/01/10

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA751238 | ENA
2022-10-13 | PXD030205 | Pride
2019-04-24 | GSE108448 | GEO
2022-05-04 | GSE190267 | GEO
2013-09-24 | E-GEOD-46430 | biostudies-arrayexpress
2006-06-09 | GSE4878 | GEO
2013-09-24 | GSE46430 | GEO
2009-09-26 | GSE17338 | GEO
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
2023-07-11 | GSE235807 | GEO