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CLIP of mRNA capping enzyme CMTR1 in Drosophila melanogaster

ABSTRACT: The mRNA cap structure consists of the m7G "cap0" linked to the 5'-most nucleotide of the initial mRNA. The first two nucleotides of mRNA can be 2'-O-Ribose modified to form cap1 or cap2 structures. Here, mRNA was sequenced after CLIP with tagged recombinant CMTR1 and compared to input RNA.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE181321 | GEO | 2021/12/18

REPOSITORIES: GEO

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CLIP of mRNA capping enzyme CMTR2 in drosophila melanogaster

Project description:The mRNA cap structure consists of the m7G "cap0" linked to the 5'-most nucleotide of the initial mRNA. The first two nucleotides of mRNA can be 2'-O-Ribose modified to form cap1 or cap2 structures. Here, mRNA was sequenced after CLIP with tagged recombinant CMTR2 enzyme and compared to input RNA.

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CLIP of mRNA capping enzyme CMTR1 in Drosophila melanogaster

Project description:CLIP of mRNA capping enzyme CMTR1 in Drosophila melanogaster

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2'-O-methylation of the second transcribed nucleotide in eukaryotic RNA 5’ cap impacts protein production levels and susceptibility to DXO-mediated transcript degradation

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Part 2 JAWS; 2'-O-methylation of the second transcribed nucleotide in eukaryotic RNA 5’ cap impacts protein production levels and susceptibility to DXO-mediated transcript degradation

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