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Functional and evolutionary impact of Mbnl2 and Mbnl3 genes in eutherian placenta

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE181335 | GEO | 2022/07/01

REPOSITORIES: GEO

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Functional and evolutionary impact of Mbnl2 and Mbnl3 genes in eutherian placenta

Project description:Functional and evolutionary impact of Mbnl2 and Mbnl3 genes in eutherian placenta

| PRJNA751590 | ENA

Evolutionary transcriptomics of Eutherian gene expression gains and the origins of decidualization

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-28 | GSE189646 | GEO

RNA-Sequencing Identifies Novel Imprinted Genes in Human Placenta

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-09-01 | E-GEOD-56781 | biostudies-arrayexpress

Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.

Project description:BackgroundA central goal of evolutionary biology is to link genomic change to phenotypic evolution. The origin of new transcription factors is a special case of genomic evolution since it brings opportunities for novel regulatory interactions and potentially the emergence of new biological properties.ResultsWe demonstrate that a group of four homeobox gene families (Argfx, Leutx, Dprx, Tprx), plus a gene newly described here (Pargfx), arose by tandem gene duplication from the retinal-expressed Crx gene, followed by asymmetric sequence evolution. We show these genes arose as part of repeated gene gain and loss events on a dynamic chromosomal region in the stem lineage of placental mammals, on the forerunner of human chromosome 19. The human orthologues of these genes are expressed specifically in early embryo totipotent cells, peaking from 8-cell to morula, prior to cell fate restrictions; cow orthologues have similar expression. To examine biological roles, we used ectopic gene expression in cultured human cells followed by high-throughput RNA-seq and uncovered extensive transcriptional remodelling driven by three of the genes. Comparison to transcriptional profiles of early human embryos suggest roles in activating and repressing a set of developmentally-important genes that spike at 8-cell to morula, rather than a general role in genome activation.ConclusionsWe conclude that a dynamic chromosome region spawned a set of evolutionarily new homeobox genes, the ETCHbox genes, specifically in eutherian mammals. After these genes diverged from the parental Crx gene, we argue they were recruited for roles in the preimplantation embryo including activation of genes at the 8-cell stage and repression after morula. We propose these new homeobox gene roles permitted fine-tuning of cell fate decisions necessary for specification and function of embryonic and extra-embryonic tissues utilised in mammalian development and pregnancy.

| S-EPMC4904359 | biostudies-literature

Epigenetics and Preeclampsia: Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-09-24 | E-GEOD-73377 | biostudies-arrayexpress

An evolutionary arms race between KRAB zinc finger genes 91/93 and SVA/L1 retrotransposons

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Functional and evolutionary significance of human microRNA seed region mutations

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-01-30 | GSE56973 | GEO

Evolutionary origin and functional divergence of stem cell homeobox genes in eutherian mammals

Project description:We individually examined the ability of human ARGFX, DPRX, LEUTX, and TPRX1 to regulate gene expression by ectopically expressing these proteins in fibroblasts.

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Global DNA Hypermethylation in Down Syndrome Placenta

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Functional and evolutionary significance of human microRNA seed region mutations

Project description:This SuperSeries is composed of the SubSeries listed below. Data for miR-429, miR-205, miR-200b, and miR-141 were each compared independently to the same negative control data contained in the raw .CEL files nc-miR-1-1.CEL, nc-miR-1-2.CEL and nc-miR-1-3.CEL. For each miRNA, the negative control data were re-normalized together with data only from that specific miRNA. The experiment for M12 was performed at a later date and an independent set of negative control data was collected at that time. Therefore, only M12 data was compared to the negative control data contained in the raw .CEL files nc-miR-2-1.CEL, nc-miR-2-2.CEL, and nc-miR-2-3.CEL.

2015-01-30 | E-GEOD-56973 | biostudies-arrayexpress

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