Transcriptomes of human myometrium in labor reveals the increased molecular associated with inflammation under hypoxia stress

ABSTRACT: Labor involves a variety of coordinated events across physiological and biochemical aspects, the molecular mechanism responsible for the transition of the myometrium from the quiescent to a contractile state remains indistinct.The global transcriptome in human non-labor and in labor myometrium was investigated through RNA sequencing (RNA-seq) to explore biological processes and pathways alterations during labor. The transcriptomic bioinformatics results showed that the up-regulated mRNAs increased inflammation under hypoxia stress in laboring myometrium.

ORGANISM(S): Homo sapiens

PROVIDER: GSE181348 | GEO | 2021/09/23

REPOSITORIES: GEO