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Profiling DNA G-quadruplex structures at single-cell level


ABSTRACT: Single-cell sequencing data uncovers cellular heterogeneity and enables studies of underlying molecular variations within cell population. Here, we adapted CUT&Tag to profile DNA secondary structure G-quadruplexes at single-cell resolution for the first time and single-cell G-quadruplex maps readily distinguished cell types in a mixed population and revealed variable frequency of G-quadruplexes observed in a given sample.

ORGANISM(S): Homo sapiens

PROVIDER: GSE181373 | GEO | 2021/12/08

REPOSITORIES: GEO

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