Transcriptomics

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A novel approach for studying mast cell-driven disorders: mast cells derived from induced pluripotent stem cells


ABSTRACT: We developed a novel strategy for the rapid and efficient differentiation of MCs from human induced pluripotent stem cells (hiPSC). These hiPSC-derived MCs (hiPSC-MCs) exhibit phenotypic and functional characteristics of human skin MCs (hsMCs) and peripheral hematopoietic stem cell-derived MCs (PSCMCs). hiPSC-MCs display stable expression of MC-associated receptors such as CD117, FcεRIα and MRGPRX2, and degranulate by stimulation with IgE/anti-IgE and Substance. P.

ORGANISM(S): Homo sapiens

PROVIDER: GSE181457 | GEO | 2022/08/31

REPOSITORIES: GEO

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