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Exportin 1 modulates lifespan by regulating nucleolar 1 dynamics via the autophagy protein LGG-1/GABARAP [RNA-seq]

ABSTRACT: RNA-seq perofrmed for studying transcriptomic changes induced by RNAi-mediated silencing of gene encoding nuclear export receptor XPO-1 in C. elegans nematodes.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE181470 | GEO | 2021/12/31

REPOSITORIES: GEO

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Exportin 1 modulates lifespan by regulating nucleolar 1 dynamics via the autophagy protein LGG-1/GABARAP [polysome RNA]

Project description:RNA-seq perofrmed for studying changes in total, monosome, and polysome-associated mRNA induced by RNAi-mediated silencing of gene encoding nuclear export receptor XPO-1 in C. elegans nematodes.

2021-12-31 | GSE181469 | GEO

Exportin 1 modulates lifespan by regulating nucleolar 1 dynamics via the autophagy protein LGG-1/GABARAP [RNA-seq]

Project description:Exportin 1 modulates lifespan by regulating nucleolar 1 dynamics via the autophagy protein LGG-1/GABARAP [RNA-seq]

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Exportin 1 modulates lifespan by regulating nucleolar 1 dynamics via the autophagy protein LGG-1/GABARAP [polysome RNA]

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Hydrogen sulfide (H2S) modulates lifespan of C.elegans

Project description:Hydrogen sulfide (H2S) is formed naturally from L-cysteine in a variety of mammalian and non-mammalian cells. To date, numerous biological effects have been ascribed to H2S including control of cardiovascular, immune and nervous function. Over or under production of H2S has been observed in several disease states including hypertension and inflammation. In addition, it has been stipulated that H2S may affect the ageing process. The model nematode Caenorhabditis elegans is ideally suited for assessing drug effects on lifespan since it is relatively short-lived, can be easily exposed to drugs and its genome is fully sequenced and widely annotated. The global transcriptome of control nematodes (raised using standardized laboratory conditions) was compared to nematodes exposed to 100 uM GYY4137 (morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate), a slow releasing H2S donor drug.

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