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Oxygen-dependent changes and lysosome activity-dependent changes of gene expression in BMDM after LPS treatment

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE181643 | GEO | 2024/04/06

REPOSITORIES: GEO

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Lysosome activity-dependent changes of gene expression in BMDM after LPS treatment

Project description:We report changes of gene expression in lysosome-inhibited BMDM after LPS treatment.

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Oxygen-dependent changes and lysosome activity-dependent changes of gene expression in BMDM after LPS treatment

Project description:Oxygen-dependent changes and lysosome activity-dependent changes of gene expression in BMDM after LPS treatment

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Oxygen-dependent changes of gene expression in BMDM after LPS treatment

Project description:We report oxygen-dependent changes of gene expression in BMDM after LPS treatment.

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Lysosome activity-dependent changes of gene expression in BMDM after LPS treatment

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:Lysosomes are a major organelle for degrading macromolecules. When deprived of nutrients, cells activate the autophagy and lysosome biogenesis pathways to recycle cytoplasmic materials and to increase lysosomal degradation capacity for survival, respectively. We have identified a condition in which cells accumulated enlarged lysosomes upon starvation and lysosome inhibition. Selective autophagy and inhibition of the mechanistic target of rapamycin (mTOR) in combination with lysosome inhibition were not able to induce this phenomenon. Conversely, knocking out autophagy genes, ATG5 or ATG7, had no effects on the enlarged lysosome formation. This suggests that the enlarged lysosome formation is an autophagy independent process. Remarkably, adding glutamine to the treatment can prevent formation of the enlarged lysosomes and dissipate the pre-existing ones. Furthermore, the nucleus/cytoplasm translocation of the transcription factor EB (TFEB), but not mTOR activity, correlates with the formation/dissipation of enlarged lysosomes. Knockdown of TFEB, however, suggests that TFEB-mediated lysosome biogenesis is not directly involved in the process. These results indicate that there is a novel mechanism by which lysosome homeostasis can be regulated under certain stress conditions.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

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