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CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE181705 | GEO | 2022/10/24

REPOSITORIES: GEO

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CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells.

Project description:The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we show that CTCF can be acetylated at lysine 20 (CTCF-K20) by CREB-binding protein (CBP) and deacetylated by histone deacetylase 6 (HDAC6). CTCF-K20 is required for the CTCF interaction with CBP. A CTCF point mutation at lysine 20 had no effect on self-renewal but blocked the mesoderm differentiation of mouse embryonic stem cells (mESCs). The CTCF-K20 mutation reduced CTCF binding to the promoters and enhancers of genes associated with early cardiac mesoderm differentiation, resulting in diminished chromatin accessibility and decreased enhancer-promoter interactions, impairing gene expression. In summary, this study reveals the important roles of CTCF-K20 in regulating CTCF genomic functions and mESC differentiation into mesoderm.

| S-EPMC9482892 | biostudies-literature

CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells [ATAC-Seq]

Project description:In this study, we show that CTCF could be acetylated at lysine 20 (CTCF-K20) by CREB binding protein (CBP) and deacetylated by HDAC6, respectively. CTCF-K20 is required for CTCF interacting with CBP. CTCF point mutation at K20 has no effect on self-renewal but blocks mesoderm differentiation of mouse embryonic stem cells (mESCs).

2022-10-24 | GSE181702 | GEO

CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells [RNA-Seq]

2022-10-24 | GSE181704 | GEO

CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells [ChIP-Seq]

2022-10-24 | GSE181703 | GEO

CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells [BL-Hi-C]

2022-10-24 | GSE181700 | GEO

CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells

Project description:CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells

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CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells [ChIP-Seq]

Project description:CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells [ChIP-Seq]