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Metformin affects transcriptomic pathways involved in cell survival, metabolism and angiogenesis in ovarian cancer cells

ABSTRACT: The objectives of the present study are to determine the effect of metformin on sphere formation, extracellular matrix invasion, and transcriptome profile of ovarian cancer (COVCAR) cells isolated from ascites of chickens that naturally developed ovarian cancer. Our results suggest that metformin treatment significantly decreased sphere formation and invasiveness of COVCAR cells. Pairwise statistical analysis of transcriptomic data using Deseq2 software revealed 0, 4, 365 genes that were differentially expressed (DEGs) in cells treated with 0.5, 1, 2 mM metformin-treated cells compared to controls, respectively.

ORGANISM(S): Gallus gallus

PROVIDER: GSE182084 | GEO | 2021/08/17

REPOSITORIES: GEO

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