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A glioma immune cell atlas identifies prognostic macrophage signatures and a novel immunotherapy target, S100A4

ABSTRACT: Here, we report defining molecular signatures of immune-suppressive and inflammatory immune cells in human gliomas. We identified nine robust macrophage subtypes with distinct molecular signatures, each of which predicted good or poor survival for glioma patients. Our analysis of signature genes associated with immune suppressive macrophages, underscored S100A4 as a strong candidate for in vivo validation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE182109 | GEO | 2021/12/15

REPOSITORIES: GEO

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A glioma immune cell atlas identifies prognostic macrophage signatures and a novel immunotherapy target, S100A4

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