Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain

ABSTRACT: After intracranial hemorrhages, heme is released from cell-free hemoglobin. This red blood cell toxin may drive secondary brain injury at the hematoma-brain interface. This study aimed to generate a spatially resolved map of the transcriptome-wide gene expression changes in the heme-exposed brain and define the potential therapeutic activity of the heme-binding protein hemopexin.

ORGANISM(S): Mus musculus

PROVIDER: GSE182127 | GEO | 2021/11/25

REPOSITORIES: GEO