Transcriptomics

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The impact of Spike protein on macrophage inflammation


ABSTRACT: Purpose: To elucidate how SARS-CoV-2 spike protein affects macrophage inflammatory responses Methods: Peritoneal macrophages were isolated from Myeloid-specific IKKβ knockout mice (IKKβΔMye) and control littermates (IKKβ F/F). Then the macrophages were treated with lentivirus expressing Spike protein for 24 hours Results: Deficiency of IKKβ nearly abolished spike protein-associated geneset scores and DEGs-associated key inflammatory pathways. Conclusions: These results indicate that SARS-CoV-2 Spike protein induces strong inflammatory responses in macrophages, potentially through activation of canonical IKKβ/NF-κB signaling

ORGANISM(S): Mus musculus

PROVIDER: GSE182264 | GEO | 2022/04/06

REPOSITORIES: GEO

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