Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic profiling for research of molecular mechanisms implicated in the differentation of Human Neural Stem Cells

ABSTRACT: We conduct RNA sequencingof the human neural stem hNS1 as a in vitro model to profile gene expression alterations in differentiation versus proliferation and we analyzed the relevance of the deregulated genes and a review of signaling pathways and analogies with previous information obtained from neural databases

ORGANISM(S): Homo sapiens

PROVIDER: GSE182285 | GEO | 2021/08/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomic profiling for research of molecular mechanisms implicated in the differentation of Human Neural Stem Cells

Project description:Transcriptomic profiling for research of molecular mechanisms implicated in the differentation of Human Neural Stem Cells

| PRJNA755664 | ENA

Tremblay.et.al.Pollen.metabarcoding

Project description:Metabarcoding data (raw, processed, scripts, databases and metadata) for a potential publication under review

| PRJEB30856 | ENA

Microarray analyses of T-ALL (COG study)

Project description:The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure or relapse. We used the Affymetrix U133 Plus 2.0 chip to profile 100 newly diagnosed patients who were treated in the Children's Oncology Group (COG) T-ALL AALL0434. We performed unsupervised hierarchical clustering of 25 HOXA probe sets within the cohort of 100 T-ALL cases. We identified a cluster of 20 cases (20%) characterized by increased expression of HOXA3, 5, 7, 9, and 10. In samples with HOXA9/10 deregulation, the presence of specific molecular lesions were confirmed through a systematic review of cytogenetic databases, FISH and PCR testing, and by RNA sequence analysis. Because MLL and AF10 genes rearrangements (MLL-R, AF10-R) are hallmarks of HOXA-deregulated leukemias, we sought to identify specific genes that are enriched with these genomic abnormalities.

2017-06-29 | GSE70536 | GEO

Transcriptome analysis by RNA-seq of ovarian cancer derived from the Cancer Institute Hospital of Japanese Foundation for Cancer Research.

Project description:We performed the RNA-seq experiments for mRNA of ovarian cancer tissue. Raw data not provided. Institutional Review Board (IRB) does not allow submitters to disclose raw data to the public

2017-08-31 | GSE101948 | GEO

The mechanism research of differentially expressed circRNAs in ALV-J-induced tumor chickens

Project description:In this study, we want to screen differentially expressed circRNAs in ALV-J-induced tumor chickens by circRNA-seq, and then conduct the mechanism research of those important circRNAs in ALV-J-induced tumor chickens

2018-11-10 | GSE99286 | GEO

Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis.

Project description:Normal extension and skull expansion is a synchronized process that prevails along the osteogenic intersections of the cranial sutures. Cranial sutures operate as bone growth sites allowing swift bone generation at the edges of the bone fronts while they remain patent. Premature fusion of one or more cranial sutures can trigger craniosynostosis, a birth defect characterized by dramatic manifestations in appearance and functional impairment. Up until today, surgical correction is the only restorative measure for craniosynostosis associated with considerable mortality. Clinical studies have identified several genes implicated in the pathogenesis of craniosynostosis syndromes with useful insights into the underlying molecular signaling events that determine suture fate. In this review, we exploit the intracellular signal transduction pathways implicated in suture pathobiology, in an attempt to identify key signaling molecules for therapeutic targeting.

| S-EPMC5144105 | biostudies-literature

Transcription profiling of human biophenotypic leukemia patients treated in St. Jude Childrens Research Hospital

Project description:Mixed-lineage leukemias represent about 3-5% of acute leukemias occurring in patients of all ages and comprise several different subtypes (biphenotypic, bilineal, and lineage switch). The optimal therapeutic approach to these cases, especially in pediatric patients, has not been defined. We used microarrays to detail the gene expression of pediatric patients with biophenotypic leukemia. Experiment Overall Design: The patient samples were selected from database review, and gene expressions were accumulated for the corresponding study period.

2009-01-14 | E-GEOD-14286 | biostudies-arrayexpress

cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.

Project description:Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular-cholangiocarcinoma." These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation. CONCLUSION:It is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H&E); immunostains are supportive, but not essential for diagnosis. (Hepatology 2018;68:113-126).

| S-EPMC6340292 | biostudies-literature

Immune effector mechanisms implicated in atherosclerosis: from mice to humans.

Project description:According to the traditional view, atherosclerosis results from a passive buildup of cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune effector mechanisms in the pathogenesis of this disease. Both innate and adaptive immunity operate during atherogenesis and link many traditional risk factors to altered arterial functions. Inflammatory pathways have become targets in the quest for novel preventive and therapeutic strategies against cardiovascular disease, a growing contributor to morbidity and mortality worldwide. Here we review current experimental and clinical knowledge of the pathogenesis of atherosclerosis through an immunological lens and how host defense mechanisms essential for survival of the species actually contribute to this chronic disease but also present new opportunities for its mitigation.

| S-EPMC3764500 | biostudies-literature

Differentation in neuroblastomas

Project description:Expression profiling according to differentiation was analysed in 34 neuroblastomas

2009-02-20 | GSE14880 | GEO