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Generation of resolving neutrophils with 4-PBA or genetic deletion of TRAM

ABSTRACT: We have generated resolving neutrophils with anti-inflammatory potency, through applying the pharmacological agent 4-PBA or genetically depleting TRAM molecule. WT murine neutrophils treated with PBS or 4-PBA for overnight were harvested for scRNAseq analysis to examine the generated resolving neutrophil phenotype. In addtion, we have cultured WT and TRAM KO neutrophils and compared the resolving phenotype via scRNAseq analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE182356 | GEO | 2022/04/20

REPOSITORIES: GEO

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