Other

Dataset Information

0

EWS-FLI1 and HOXD13 control tumor cell plasticity in Ewing sarcoma [CUT&RUN]


ABSTRACT: Posterior homeobox D genes, in particular HOXD13, are over-expressed by Ewing sarcoma, a tumor driven by the oncogenic fusion protein EWS-FLI1. Here, we have found that EWS-FLI1 maintains HOXD13 expression through a GGAA microsatellite enhancer in the developmental posterior HOXD regulatory domain. RNA-seq of shHOXD13 defined HOXD13-ergulated genes, so we performed CUT&RUN for HOXD13 and histone marks (H3K27ac, H3K4me3, H3K4me1, and H3K27me3) to determine how it regulates target genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE182512 | GEO | 2022/06/28

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-06-28 | GSE148494 | GEO
2022-06-28 | GSE165973 | GEO
2022-10-18 | GSE189418 | GEO
| PRJNA756547 | ENA
2018-07-25 | GSE108631 | GEO
2017-10-22 | GSE94502 | GEO
2017-10-22 | GSE94480 | GEO
2023-10-23 | GSE220780 | GEO
2024-01-26 | PXD041033 | Pride
| PRJNA624652 | ENA