Transcriptomics

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DEN-induced rat model reproduces key features of human hepatocellular carcinoma


ABSTRACT: Using RNA-seq analysis, we study a DEN-induced HCC rat model during fibrosis progression and HCC development with special focus on liver inflammatory microenvironment. RNA-seq results show that DEN-induced liver tumors in rat model share remarkable molecular characteristics with human HCC, especially with HCC associated with high proliferation. In conclusion, our study provides detailed insight into the hepatocarcinogenesis in a commonly used model of HCC, facilitating the future use of this model for preclinical testing.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE182860 | GEO | 2021/10/08

REPOSITORIES: GEO

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