Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Liver p53-dependent gene expression 48hrs after Mdm2Ex5/6Δ (Mdm2tm2.1Glo) allele activation

ABSTRACT: Liver samples were taken from mice homozygous for the Mdm2Ex5/6Δ (Mdm2tm2.1Glo) allele at 48 hrs post-AAV treatment to observe gene expression after ubiquitous p53 stabilisation.

ORGANISM(S): Mus musculus

PROVIDER: GSE183082 | GEO | 2021/10/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Liver p53-dependent gene expression 48hrs after Mdm2Ex5/6Δ (Mdm2tm2.1Glo) allele activation

Project description:Liver p53-dependent gene expression 48hrs after Mdm2Ex5/6Δ (Mdm2tm2.1Glo) allele activation

| PRJNA759128 | ENA

Tribbles-1 regulates hepatic lipogenesis through post-transcriptional regulation of C/EBPα [array]

Project description:Comparison of gene expression in livers of either WT mice or mice with hepatic specific deletion of the gene Tribbles1. Animal groups were both Trib1 cKO mice homozygous for a floxed allele of Trib1. Mice aged 8-10 weeks were treated with adeno associated virus (AAV) encoding Cre recombinase (AAV_Cre) or no gene (AAV_null). The WT group is mice treated with AAV_Null, the liver-specific KO group treated with AAV_Cre. Gene expression data was then used in Ingenuity Pathway analysis to attempt to identify upstream transcription factors that might be responsible for the gene expression changes observed. All animals were 8-10 weeks of age, and all animals were homozygous for the floxed allele of Trib1. WT animals were treated with AAV_Null, Trib1 liver specific KO mice were treated with AAV_Cre. Mice were euthanized at 1-week post injection of AAV, and RNA collected from whole liver tissue.

2015-07-14 | E-GEOD-70846 | biostudies-arrayexpress

aCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas

Project description:Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood solid tumours and severe chromosomal instability. In contrast to BRCA1- or BRCA2-associated cancers, breast tumours in heterozygous PALB2 mutation carriers do not show loss of the wild type allele, suggesting PALB2 might be haploinsufficient for tumour suppression. To study the role of PALB2 in development and tumourigenesis, we have generated Palb2GT mouse mutants using a gene trap approach. Whereas Palb2GT/GT homozygous mutant embryos died at mid-gestation due to massive apoptosis, Palb2GT/+ heterozygous mice were viable and did not show any obvious abnormalities. Deletion of p53 alleviated the phenotype of Palb2GT/GT embryos, but did not rescue embryonic lethality. In addition, loss of p53 did not significantly collaborate with Palb2 heterozygosity in tumourigenesis in heterozygous or homozygous p53 knockout mice. Tumours arising in Palb2GT/+;p53+/– or Palb2GT/+;p53–/– compound mutant mice retained the wild type Palb2 allele and did not display increased genomic instability.

2011-01-21 | GSE26723 | GEO

aCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas

2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress

Bulk segregant RNA seq samples from young leaf tissue of sesame seedlings with either SiCD-A or SiCD-B allele

Project description:Transcriptome analysis was performed on young leaves from 17-day old sesame seedling. The experiment aimed to shed light on the polar regulatory gene network in sesame under KANADI1 loss of function and identify candidate genes underlie the hyponastic leaf phenotype. We compaired between homozygous lines for either SiCD-A allele contains KAN1 (WT) or SiCD-B allele contains kan1 (mutant) on S.indicum LG8.

2022-01-10 | GSE164511 | GEO

HLA New Allele

Project description:DRB1*New Allele

| PRJEB34364 | ENA

A genome-wide analysis reveals that the Drosophila transcription factor, Lola, promotes axon growth in part by suppressing expression of the actin nucleation factor, Spire (allele lola_ORE76)

Project description:Transcriptional profiling of Drosophila embryos comparing lola mutant 10-12 hour after egg lay (AEL) embryos to age-matched control embryos. Mutants are homozygous lola nulls (allele lola_ORE76).

2011-12-03 | GSE34121 | GEO

Gene expression of breast tumors with mutant p53 or mutant p53 deleted [RNA-seq]

Project description:We conducted gene expression analysis from total tumor treated with AAV-Control or AAV-mut-p53 deleted.

2023-08-18 | GSE213822 | GEO

A genome-wide analysis reveals that the Drosophila transcription factor, Lola, promotes axon growth in part by suppressing expression of the actin nucleation factor, Spire (allele lola_ORC4)

2011-12-03 | GSE34122 | GEO

scRNA gene expression of breast tumors with mutant p53 or mutant p53 deleted [scRNA-seq]

Project description:We conducted gene expression analysis from total tumor treated with AAV-Control or AAV-mut-p53 deleted in an acute setting.

2024-01-01 | GSE213823 | GEO